Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network
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A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage
The bacterial SOS stress-response pathway is a pro-mutagenic DNA repair system that mediates bacterial survival and adaptation to genotoxic stressors, including antibiotics and UV light. The SOS pathway is composed of a network of genes under the control of the transcriptional repressor, LexA. Activation of the pathway involves linked but distinct events: an initial DNA damage event leads to ac...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2018
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007405